MMP-2
MMP-2 is involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the activation of MMP-2 is cell-cell clustering. A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr4017 | Recombinant Human MMP-2 Protein (aa 1-660) | Human | Recombinant Human MMP-2 Protein (Met 1-Cys660) was expressed in HEK293 Cells, with a molecular weight of 72 kDa. (Accession ID: NP_004521.1) | MMP-2 | Tumor Antigens |  |
20 µg | Inquiry |
| VAng-Cr4018 | Recombinant Mouse MMP-2 Protein (aa 409-622) [His] | Mouse | Recombinant Mouse MMP-2 Protein (Met409-Cys622) fused with a His tag at N-terminus was expressed in HEK293 Cells, with a molecular weight of 30.9 kDa. (Accession ID: NP_032636.1) | MMP-2 | Tumor Antigens | |
5 µg | Inquiry |
| VAng-2570Lsx | Human MMP-2 Protein (Ala 30-Cys 660) [His] | HEK293 cells | Human MMP-2 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH02576) | MMP-2 | Tumor Antigens | |
50 µg | Inquiry |
| VAng-2571Lsx | Human MMP-9 Protein (Ala 20-Pro 469) [His] | HEK293 cells | Human MMP-9 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH06093) | MMP-2 | Tumor Antigens | |
50 µg | Inquiry |
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
