OX40

OX40 is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels. It has no effect on the proliferative abilities of CD4+ cells for the first three days, however after this time proliferation begins to slow and cells die at a greater rate, due to an inability to maintain a high level of PKB activity and expression of Bcl-2, Bcl-XL and survivin.

CAT	Product Name	Source	Product Overview	Target	Type	Size	Price
VAng-Cr3829	Recombinant OX40 Protein (Met1-Ala216) [His]	Mammalian cells	Recombinant OX40 Protein (Met1-Ala216) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40-45 kDa. (Uniprot ID: P43489)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2627Lsx	Biotinylated Mouse OX40 Protein (Val 20-Pro 211) [His] [Avi]	HEK293 cells	Biotinylated Mouse OX40 protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: P47741-1)	OX40	Tumor Antigens	25 µg	Inquiry
VAng-2628Lsx	Human OX40 Protein (Leu 29-Ala 216) [Mouse IgG2a Fc Tag]	HEK293 cells	Human OX40 protein, Mouse IgG2a Fc Tag, was expressed in human 293 cells. (Uniprot ID: P43489-1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2629Lsx	Marmoset OX40 Protein (Leu 29-Ala 214) [His]	HEK293 cells	Marmoset OX40 protein, His tag, was expressed in human 293 cells. (Uniprot ID: F7DHA3-1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2630Lsx	Biotinylated Human OX40 Protein (Leu 29-Ala 216) [His] [Avi]	HEK293 cells	Biotinylated Human OX40 protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: NP_003318.1)	OX40	Tumor Antigens	25 µg	Inquiry
VAng-2631Lsx	Rat OX40 Protein (Val 20-Pro 210) [Fc]	HEK293 cells	Rat OX40 protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: P15725)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2632Lsx	Rabbit OX40 Protein (Ala 19-Gln 208) [Fc]	HEK293 cells	Rabbit OX40 protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: O02764)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2633Lsx	Biotinylated Human OX40 Protein (Leu 29-Ala 216) [Fc] [Avi]	HEK293 cells	Biotinylated Human OX40 protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: NP_003318)	OX40	Tumor Antigens	25 µg	Inquiry
VAng-2634Lsx	Rhesus macaque OX40 Protein (Lys 28-Ala 214) [Fc]	HEK293 cells	Rhesus macaque OX40 protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: XP_001090870.1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2635Lsx	Rhesus macaque OX40 Protein (Lys 28-Ala 214) [His]	HEK293 cells	Rhesus macaque OX40 protein, His tag, was expressed in human 293 cells. (Uniprot ID: XP_001090870.1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2636Lsx	Mouse OX40 Protein (Val 20-Pro 211) [Fc]	HEK293 cells	Mouse OX40 protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_035789)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2637Lsx	Mouse OX40 Protein (Val 20-Pro 211) [His]	HEK293 cells	Mouse OX40 protein, His tag, was expressed in human 293 cells. (Uniprot ID: P47741-1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2638Lsx	Human OX40 Protein (Leu 29-Ala 216) [His]	HEK293 cells	Human OX40 protein, His tag, was expressed in human 293 cells. (Uniprot ID: P43489-1)	OX40	Tumor Antigens	100 µg	Inquiry
VAng-2639Lsx	Human OX40 Protein (Leu 29-Ala 216) [human IgG1 Fc tag]	HEK293 cells	Human OX40 protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_003318)	OX40	Tumor Antigens	100 µg	Inquiry

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