TNFRSF4
TNFRSF4 is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels. It has no effect on the proliferative abilities of CD4+ cells for the first three days, however after this time proliferation begins to slow and cells die at a greater rate, due to an inability to maintain a high level of PKB activity and expression of Bcl-2, Bcl-XL and survivin.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3801 | Recombinant TNFRSF4 Protein (Met1-Ala216) [His] | Mammalian cells | Recombinant TNFRSF4 Protein (Met1-Ala216) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40-45 kDa. (Uniprot ID: P43489) | TNFRSF4 | Tumor Antigens |  |
100 µg | Inquiry |
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