What is the primary use of the Anti-MIgG(Fc)-C-DX8951 ADC?

The Anti-MIgG(Fc)-C-DX8951 ADC is primarily used for targeting and binding to mouse IgG Fc regions, leveraging its conjugated topoisomerase I inhibitor, exatecan mesylate (DX8951), for research and therapeutic purposes.

How does the cleavable linker in the ADC function?

The cleavable linker in the Anti-MIgG(Fc)-C-DX8951 ADC enables the controlled release of the cytotoxic agent DX8951 upon reaching the target site, enhancing the specificity and reducing off-target effects in experimental applications.

What are the key physiological effects mediated by the Fc region of IgG in this ADC?

The Fc region of IgG mediates various physiological effects such as opsonization, antibody-dependent cellular cytotoxicity (ADCC), and degranulation of mast cells, basophils, and eosinophils by binding to cell receptors and complement proteins.

What role does glycosylation play in the function of the Anti-MIgG(Fc)-C-DX8951 ADC?

Glycosylation of the Fc fragment is crucial for Fc receptor-mediated activities, ensuring proper binding to receptors and complement proteins, which is essential for the effective physiological action of the ADC.

What are the potential applications of the Anti-MIgG(Fc)-C-DX8951 ADC in research?

The Anti-MIgG(Fc)-C-DX8951 ADC can be used in various research applications, including studies on antibody mechanisms, Fc receptor interactions, and the therapeutic potential of topoisomerase I inhibitors in cancer research.

Are there any specific storage conditions for the Anti-MIgG(Fc)-C-DX8951 ADC to ensure its stability?

To maintain the stability and efficacy of the Anti-MIgG(Fc)-C-DX8951 ADC, it is recommended to store the product at -80°C, protected from light and moisture, and to avoid repeated freeze-thaw cycles.

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Anti-MIgG(Fc)-C-DX8951 ADC

Anti-MIgG(Fc)-C-DX8951 ADC (CAT#: ADC-AA-061)

This ADC product is comprised of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to exatecan mesylate (DX8951). DX8951 is a topoisomerase I inhibitor.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Alternative Names
Immunoglobulin G; IgG; Fc

Overview
The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

Overview
Anti-mouse IgG Fc specific polyclonal IgG antibody

Species Reactivity
Mouse

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulﬁde-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.

Name
DX8952

Description
DX8951, a novel water-soluble camptothecin analog, is a DNA topoisomerase I inhibitor.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

Highly Efficient ADC

This ADC is highly effective in our experiments. The DX8951 conjugate worked perfectly, providing clear and reproducible results. Excellent choice!

Excellent

Reliable and Potent

The topoisomerase I inhibitor component showed great activity. The product's stability and performance exceeded our expectations. Very pleased with the results.

Excellent

Excellent Specificity

The anti-mouse IgG Fc specificity was impressive. Combined with the cleavable linker, it provided precise and accurate results in our assays.

Excellent

Great for Research

This ADC was a valuable addition to our lab. The Fc region glycosylation ensured effective Fc receptor-mediated activity, enhancing our experimental outcomes.

Excellent

Impressive Performance

The product delivered consistent and reliable results. The DX8951 component was highly potent, making it ideal for our cellular studies.

Excellent

Cost-Effective Solution

This ADC is both economical and efficient. It provided high-quality results with minimal background interference, making it a great investment for our research.

Q: 1: What is the primary use of the Anti-MIgG(Fc)-C-DX8951 ADC?
A: The Anti-MIgG(Fc)-C-DX8951 ADC is primarily used for targeting and binding to mouse IgG Fc regions, leveraging its conjugated topoisomerase I inhibitor, exatecan mesylate (DX8951), for research and therapeutic purposes.
Q: 2: How does the cleavable linker in the ADC function?
A: The cleavable linker in the Anti-MIgG(Fc)-C-DX8951 ADC enables the controlled release of the cytotoxic agent DX8951 upon reaching the target site, enhancing the specificity and reducing off-target effects in experimental applications.
Q: 3: What are the key physiological effects mediated by the Fc region of IgG in this ADC?
A: The Fc region of IgG mediates various physiological effects such as opsonization, antibody-dependent cellular cytotoxicity (ADCC), and degranulation of mast cells, basophils, and eosinophils by binding to cell receptors and complement proteins.
Q: 4: What role does glycosylation play in the function of the Anti-MIgG(Fc)-C-DX8951 ADC?
A: Glycosylation of the Fc fragment is crucial for Fc receptor-mediated activities, ensuring proper binding to receptors and complement proteins, which is essential for the effective physiological action of the ADC.
Q: 5: What are the potential applications of the Anti-MIgG(Fc)-C-DX8951 ADC in research?
A: The Anti-MIgG(Fc)-C-DX8951 ADC can be used in various research applications, including studies on antibody mechanisms, Fc receptor interactions, and the therapeutic potential of topoisomerase I inhibitors in cancer research.
Q: 6: Are there any specific storage conditions for the Anti-MIgG(Fc)-C-DX8951 ADC to ensure its stability?
A: To maintain the stability and efficacy of the Anti-MIgG(Fc)-C-DX8951 ADC, it is recommended to store the product at -80°C, protected from light and moisture, and to avoid repeated freeze-thaw cycles.

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ADC-AA-021	anti-MIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
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CAT#	Product Name	Linker	Payload
ADC-AA-010	anti-HIgG(Fc)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
WJY-0423-LS107	Protein A-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
ADC-AA-028	anti-MIgG(Fc)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-062	Anti-HIgG(Fc)Fab-C-DX8951 ADC	Cleavable linkers	DX8953
ADC-AA-017	anti-HIgG(Fab)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)

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