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- anti-HIgG(Fc)-C-MMAF ADC
anti-HIgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-002)
This ADC product is comprised of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAF. The antibody portion is a secondary antibody and the drug portion, MMAF, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fc
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Overview
- anti-human IgG Fc specific polyclonal IgG antibody
- Species Reactivity
- Human
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-MIgG (clone HB43)-VC-MMAE ADC (CAT#: ADC-AA-057)
- anti-MIgG(Fc)Fab-N-DM1 ADC (CAT#: ADC-AA-031)
- anti-MIgG(Fc)-C-DMSA ADC (CAT#: ADC-AA-023)
- anti-MIgG(Fc)-C-MD10 ADC (CAT#: ADC-AA-022)
- anti-HIgG(Fc)Fab-C-DMDM ADC (CAT#: ADC-AA-013)
- anti-HIgG(Fc)-C-MD10 ADC (CAT#: ADC-AA-004)
- anti-MIgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-020)
- Protein G-MMAF ADC (CAT#: ADC-AA-049)
- anti-HIgG(Fc)-C-DMDM ADC (CAT#: ADC-AA-006)
- Anti-HIgG(Fab)-C-MMAF ADC (CAT#: ADC-AA-064)
Published Data
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Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-AA-002. Click the button above to contact us or submit your feedback about this product.
Customer Reviews
FAQ
Excellent
Highly recommend The anti-HIgG(Fc)-C-MMAF ADC is exceptional for our research. Its ability to target and kill cancer cells efficiently makes it indispensable in our lab.
Excellent
We've seen significant advancements in our cancer studies using anti-HIgG(Fc)-C-MMAF ADC. The targeted delivery of MMAF and cell death induction are remarkable
Excellent
The cleavable linker used in this product ensures precise targeting and effective delivery of the cytotoxic agent. Very satisfied with the results!
Excellent
The efficiency of anti-HIgG(Fc)-C-MMAF ADC in disrupting microtubule dynamics and inducing cell death has made it a valuable asset in our research.
Excellent
The anti-HIgG(Fc)-C-MMAF ADC has proven to be an excellent tool in our cancer research, providing effective and safe results. Creative Biolabs has done a great job with this product!
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-026 | anti-MIgG(Fc)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-050 | Protein G-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-055 | Protein A-Duocarmycin ADC | Duocarmycins |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-003 | anti-HIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-061 | Anti-MIgG(Fc)-C-DX8951 ADC | Cleavable linkers | DX8952 |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-020 | anti-MIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-010 | anti-HIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-049 | Protein G-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-AA-053 | Protein A-MMAF ADC | MMAF (Monomethyl auristatin F) |
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