Close

Angiotensin II Receptor Family

The angiotensin II receptor family is composed of two receptors: AGTR1 and AGTR2. They belong to the G-protein-coupled receptor family and they bind angiotensin II as their ligands. Angiotensin II is a multifunctional peptide hormone and the principle effector molecule of the renin-angiotensin system (RAS) that regulates a variety of biological functions, including regulation of blood pressure, plasma volume, and cardiac, renal and neuronal functions, and thirst responses. AGTR1 mediates the classic physiological effects of Angiotensin II, such as vasoconstriction, aldosterone, and vasopressin, sodium and water retention, sympathetic facilitation, cell proliferation, etc. On the other hand, AGTR2 may exhibit opposing biological functions. This receptor is more plentiful in fetus and neonate. Studies have reported a role for AGTR2 in cardiovascular, brain, and renal function as well as in cell differentiation, tissue repair, and apoptosis.

Since angiotensin II receptors are involved in so many physiological processes and the pathophysiology of different diseases, they have been extensively studied and therapeutic interventions have also been developed. Here, we give an introduction of these two human angiotensin II receptors regarding the structure, signaling pathway, biological functions, etc.

Human Angiotensin II Receptor Members
AGTR1 AGTR2

For biochemical and biophysical characterization, it is necessary for membrane proteins to be isolated from their native amphipathic environments and introduced into an artificial environment that is expected to preserve their structural integrity and function. Creative Biolabs has developed a robust platform for the preparation of purified, stable, and functional membrane proteins, enabling detailed in vitro investigation of their structures and for further applications. Please see Magic™ membrane protein production platform, where you can prepare your target proteins into different systems, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers.

Angiotensin II Receptor Family

Meanwhile, our Magic™ membrane protein antibody discovery platform helps to develop antibodies against these membrane protein antigens, using unparalleled hybridoma and phage display technologies. We also present DNA immunization service for anti-membrane protein antibody development. contact us to experience the great value of our expert services.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us