Anti-FMC63 scFv Monoclonal Antibody, Biotin-Conjugated (CAR-AB-ZP2)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

FMC63 is a CD19-specific IgG1 mouse monoclonal antibody, which is a target for immunotherapy of B-lineage leukemia and lymphoma. FMC63 scFv is the most commonly used extracellular domain component of CD19-specific CARs. So far, most of the reported CART-CD19 clinical trials contain anti-CD19 scFv derived from FMC63, such as the two FDA-approved CARs Kymriah and Yescarta. This product was verified to specifically recognize the antigen recognition domain of FMC63-derived CAR.

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Details

Target
CD19

Targeting Cell Type
CAR-T Cell

Isotype
IgG1/kappa

Specificity
Specifically recognizes the antigen-recognition domain of FMC63 derived CARs.

Conjugation
Biotin

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Bioactivity
The activity was evaluated by FACS. Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution Biotin-Labeled Monoclonal Anti-FMC63 scFv Antibody and isotype control respectively. Biotin signal was used to evaluate the binding activity (QC tested).

Reconstitution
For best performance, please see the reconstitution protocol provided in the CoA.

Target

Host Animal
Mouse

Expression
This product is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with FMC63 scFv.

Target Species
Human

Gene ID
930

Related Resources

Overview of CD19-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.