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The vector of anti-PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PSCA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-PSCA antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Prostate cancer.
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CAR Construction :
Fig.1 The mAb 8D11 binds to PSCA-expressing HT1376 cells. Cell surface expression of PSCA on HT1376 cells as detectedby flowcytometry analysis using the anti-PSCA mAb 8D11. Morgenroth, A., Cartellieri, M., Schmitz, M., Günes, S., Weigle, B., Bachmann, M., ... & Temme, A. (2007). Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T‐cells. The Prostate, 67(10), 1121-1131. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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