Leukemia-Specific CAR Construction Service

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

As a leading service provider, Creative Biolabs provides customer with first-class CellRapeutics™ Chimeric Antigen Receptor (CAR) targets various leukemia-specific antigens. Our excellent scientists with many years of experience have successfully established a unique and unparalleled CAR construction and production platform.

Fig.1 CAR-T cells act on targeted cancer cells. (Majumder, 2023) Fig.1 Typical mechanism of action between CAR-T cells and targeted cancer cells.¹

Leukemia is a type of blood cancer, which starts in the bone marrow and subsequently leads to large amount of abnormal white blood cells (WBCs). These WBCs which lose normal function and grow quickly and finally crowd out the normal ones. It can be further divided into four main subtypes: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML). According to the onset of leukemia, ALL and AML develop quickly; while CLL and CML perform slowly. The cause of leukemia is still unknown. However, several factors have been characterized to play key roles in the arising of leukemia, such as gene mutation which may be caused by chemical exposure or radiation exposure, viral infection and heredity such as a family history of Leukemia or Down syndrome. Leukemia is usually treated with chemotherapy, radiation therapy, and stem cell transplantation if possible. However, chemotherapy and radiation therapy always have serious side effects and potential complications. Emerging studies have shown adoptive immunotherapy such as CAR modified T cells or NK cells therapy that is the most promising approach for cancer treatment, which can get over the adverse effects of traditional therapies.

Creative Biolabs now provides you with custom construction and production services of many types of CARs against Leukemia antigens including CD19, k-light chain, CD33, CD123, WT1, Pr3, HNE, survivin and OFA-iLRP, all of which are listed in the following table. Different types of CARs and various styles of generation are also shown in this table. Besides these, we also have highly tailored service to meet the most specific needs from customers. If you need any help about CARs, please feel free to contact us.

Products against Leukemia-specific antigens

Associated malignancy	Target antigen	Receptor type	Product
Acute lymphoblastic leukemia (ALL)	CD22	scFv-CD28-41BB-CD3ζ	CAR-T-3-M308-2BZ
	CD47	scFv-CD28-41BB-CD3ζ	CAR-T-3-L344-2BZ
	PD-1	scFv-CD28	CAR-T-1-L345-2
	PD-1	scFv-CD28-CD3ζ	CAR-T-2-L345-2Z
	MICA	scFv-CD28-41BB-CD3ζ	CAR-T-3-L345-2BZ
	CD5	scFv-CD28-CD3ζ	CAR-LC173
	TSLPR	scFv-CD3ζ	CAR-MZ093
	TSLPR	scFv-41BB-CD3ζ	CAR-LC189
	CD123	scFv-CD28-CD3ζ	CAR-LC028
	CD33	scFv-CD28-CD3ζ	CAR-MZ158
	CD44v6	scFv-LNGFR-CD28-CD3ζ	CAR-LC346
Acute myeloid leukaemia (AML)	CLEC12A	scFv-CTLA4-CD3ζ	CAR-MZ002
	FRβ (Folate receptor-beta)	scFv-CD3ζ	CAR-LC167
	FRβ (Folate receptor-beta)	scFv-CD28-CD3ζ	CAR-LC168
	LeY	scFv-CD28-41BB-CD3ζ	CAR-T-3-M320-2BZ
Chronic lymphocytic leukemia (CLL)	237 epitope	scFv-CD28-CD3ζ	CAR-MZ103
	B7-H6	scFv-CD28-CD3ζ-T2A-CD19t	CAR-LC349
	CD19	scFv-CD3ζ	CAR-LC184
		scFv-CD28-CD3ζ	CAR-LC185
		scFv-CD28-41BB-CD3ζ	CAR-LC231
	CD20	scFv-CD3ζ	CAR-MZ056
	CD20	scFv-CD28-CD3ζ	CAR-MZ057
	CD23	scFv-CD3ζ	CAR-MZ206
	CD276	scFv-CD3ζ	CAR-T-1-L334-Z
	CD70	scFv-CD28-FcεRIγ	CAR-T-2-L405-2G
	ROR1	scFv-CD28-CD3ζ	CAR-LC215
	TOSO	scFv-CD28-CD3ζ	CAR-LC125
	ITGB3	scFv-CD28-41BB-CD3ζ	CAR-T-3-L339-2BZ
	IGK	scFv-CD28-41BB-CD3ζ	CAR-T-3-M403-2BZ
Chronic myeloid leukemia (CML)	FKBP5	scFv-CD28-OX40-CD3ζ	CAR-T-3-L409-2XZ

Reference

Majumder, Avisek. “Evolving CAR-T-cell therapy for cancer treatment: from scientific discovery to cures.” Cancers. (2023) 16,1 39.