Mouse Cell Products

Animal cells serve as important cell tools in biomedical research. Researchers can utilize animal cells as models for human systems to study various disease mechanisms and evaluate new therapies in animal models. This allows them to gather valuable insights before applying the findings to humans. Mice play a crucial role as models for studying both normal and pathological processes in humans. The advantages of this model include its affordability, rapid reproduction, and close genetic resemblance to humans. Cells from mice possess a wide range of benefits and are a powerful tool for scientists to investigate the development of diseases. The use of mouse cells is seeing a notable rise.

Fig.1 Murine preclinical cancer modeling.¹

Isolation of Mouse Cells

Generally, mouse cell isolation involves several key steps, such as digestion, extraction, purification, viability test, and cell culture. It is important to be mindful of preventing bacterial contamination during the operation. Here, we will utilize the purification of T cells from mouse spleen as an example. Initially, euthanasia mice follow the institutional protocols. After washing, filtering, dilacerating, centrifuging, lysing, and culturing, gather the spleen. Following splenic cell harvesting, T cells are purified in accordance with the mouse T cell isolation kit for internal usage inside the organization and characterized by flow cytometry using particular markers. The fundamental operational concept behind the separation of primary cells from various tissues is generally consistent but with variations in the specific procedural methods used.

Benefits of Mouse Cells

• Physiological and Genetic Similarities: Mice share significant physiological and genetic similarities with humans. Mouse cells can be utilized to investigate a wide range of biological processes of human cells, such as the onset and progression of diseases.
• Easy to Obtain and Culture: Obtaining mouse cells is a straightforward process, and they can be readily expanded and propagated through cell culture techniques. Additionally, mouse cells are highly amenable to genetic manipulation, making it easy to conduct experiments such as gene knockout or knock-in.
• Wide Applications: Mouse cells are extensively utilized in a range of biological and medical research areas, such as tumor research, drug screening, and vaccine development. Studying mouse cells allows scientists to gain a deeper understanding of the growth and differentiation processes of human cells. This knowledge provides valuable clues and serves as a foundation for advancements in clinical medicine.

In summary, the utilization of mouse cells allows for the simulation of the human environment, leading to more precise research findings and valuable contributions to scientific research and clinical medicine.

Mouse Cells at Creative Biolabs

In order to cater to the demands of our global customers, Creative Biolabs offers a diverse range of readily used mouse cell products that have undergone rigorous quality assurance measures. Our diverse range of mouse cells at Creative Biolabs is perfectly suited to your research requirements. Feel free to contact us at any time to inquire for more information about our products.

Reference

1. Hicks, William H., et al. "Contemporary mouse models in glioma research." Cells 10.3 (2021): 712.