Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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Cytokine-induced killer (CIK) cells, a type of immune cell characterized by a unique phenotype and potent antitumor activity, are increasingly used in cancer immunotherapy. To ensure the efficacy, safety, and quality of CIK cell-based therapies, a thorough understanding of their functional properties is essential. Our CIK in vitro characterization services are designed to provide crucial insights into CIK cell functionality across multiple parameters, including tumor cell cytotoxicity, cytokine and chemokine secretion, immune exhaustion, apoptosis, aging-related changes, and microbiological contamination.
Fig.1 CIK cell-based therapy.1
CIK-Tumor Cells Cytotoxicity Analysis
The primary therapeutic potential of CIK cells lies in their ability to recognize and kill tumor cells. Our service assesses the ability of CIK cells to target and eliminate cancerous cells. Using advanced flow cytometry and other quantitative assays, we measure the cytotoxic activity of CIK cells against a variety of tumor cell lines.
CIK Cytokine/Chemokine Analysis
Our CIK Cytokine/Chemokine Analysis service quantifies the production of key immune mediators such as IFN-γ, TNF-α, IL-2, IL-6, IL-10, and others in response to tumor stimuli or activation. This analysis provides valuable insights into the inflammatory and immune regulatory functions of CIK cells.
CIK Exhaustion Analysis
Our CIK exhaustion analysis evaluates markers of T-cell exhaustion such as PD-1, CTLA-4, Tim-3, and LAG-3, which are commonly upregulated in fatigued immune cells. Understanding the exhaustion profile of CIK cells helps assess their functional capacity and can guide strategies to rejuvenate or enhance their antitumor activity.
CIK Apoptosis Analysis
Our service monitors the rate of apoptosis in CIK cells under various conditions, including in the presence of tumor cells or after prolonged in vitro expansion. This analysis helps determine the survival and stability of CIK cells, providing essential information about their longevity and functionality in therapeutic applications.
CIK Aging-related Analysis
Our service assesses age-related markers, such as telomere shortening, mitochondrial dysfunction, and changes in cell surface markers (e.g., CD28, CD57). This analysis enables the identification of cellular aging in CIK populations, allowing researchers to optimize cell expansion protocols and enhance the overall therapeutic performance of CIK cells.
CIK Microbiological Contamination Analysis
To ensure the purity and safety of CIK cell preparations, we offer CIK microbiological contamination analysis service including testing for bacterial, fungal, and mycoplasma contamination. Through rigorous microbial screening, we ensure that CIK cell preparations meet the highest safety standards for clinical applications.
At Creative Biolabs, our CIK in vitro characterization services are designed to provide in-depth insights into the functional properties and safety of CIK cells, facilitating the development of robust and effective immunotherapies. Whether assessing tumor cell cytotoxicity, immune modulation, exhaustion, or cellular aging, our services ensure that CIK cells meet the rigorous demands of modern cancer immunotherapy. For researchers and developers looking to optimize CIK cell-based therapies, our expert team is ready to provide customized solutions to support every stage of your project.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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