Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-CD56 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD56. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD56 antibody linked to CD137 (4-1BB) and CD3-zeta signaling domains. And the vector product was designed for the treatment of relapsed refractory myeloma.
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CAR Construction : N901-CD28-CD3ζ
Fig.1 CD56R-specific CAR T cells kill CD56-expressing targets in vitro. Chromium release assays of CD56R-CAR+ T cells co-cultured 20:1 with the following targets: Neuroblastoma (CHLA-255, IMR-32, SKN-BE, and SK-N-SH) and SCLC (HTB-119) cell lines; NK-cell leukemia (KHYG1) and glioma/astrocytoma (U87) cell lines. Crossland, D. L., Denning, W. L., Ang, S., Olivares, S., Mi, T., Switzer, K., ... & Heymach, J. V. (2018). Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models. Oncogene, 37(27), 3686-3697. |
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CAR Construction : N901-CD28-CD3ζ
Fig.2 Anti- or pro-tumor cytokine expression. Expression anti- or pro-tumor cytokine of CD4+ and CD8+ CD56R-CAR+ T cells was detected by intracellular flow cytometry after culturing CD3+ CD56R-CAR+ T cells in the diffrent conditions. Crossland, D. L., Denning, W. L., Ang, S., Olivares, S., Mi, T., Switzer, K., ... & Heymach, J. V. (2018). Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models. Oncogene, 37(27), 3686-3697. |
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CAR Construction :
Fig.3 The ability of CD56R-CAR+T to control tumor growth in vivo. CD56R-CAR+ T cells inhibit the growth of human CD56+ tumors in the high/low tumor-burden CD56+ neuroblastoma mouse model.. Crossland, D. L., Denning, W. L., Ang, S., Olivares, S., Mi, T., Switzer, K., ... & Heymach, J. V. (2018). Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models. Oncogene, 37(27), 3686-3697. |
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