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As a leader in the field of CAR-T therapy development, Creative Biolabs offers a comprehensive series of GYPA molecular-related products to support researchers in their quest to develop innovative and effective treatments. To find the appropriate product for you, please look through the list below.
C3AR1 (complement component 3a receptor 1) is a protein that is involved in the immune system response. It is a receptor that binds to the complement component C3a, which is a part of the innate immune system. The activation of C3AR1 by binding to C3a can lead to a series of cellular responses, including the release of pro-inflammatory mediators, chemotaxis of immune cells, and modulation of adaptive immune responses. It has been found that C3AR1 expression is dysregulated in certain types of cancer, including breast, lung, and colorectal cancer. C3AR1 has been implicated in both tumor promotion and inhibition, depending on the context and specific tumor type. For example, studies have shown that C3AR1 expression is upregulated in breast cancer cells and is related to enhanced migration and invasion abilities. Targeting C3AR1 in cancer therapy has shown promise in preclinical studies and is an area of ongoing research.
Fig.1 Structure of C3aR:C3a.1
Breast cancer
Lung cancer
Colorectal cancer
CAR-T in vitro assays enable researchers to evaluate the efficacy and safety of CAR-T cells before implementing them in clinical trials. At Creative Biolabs, we provide various in vitro assays used to assess the function and behavior of anti-C3AR1 CAR-T cells. By utilizing these in vitro assays, researchers can gain valuable insights into the behavior and function of anti-C3AR1 CAR-T cells, guiding the development of more effective CAR-T-based cancer therapies. Our services include the following assays:
In order to further validate the results obtained from the in vitro experiments, we have also developed in vivo models and assays to analyze the impact of anti-C3AR1 CAR-T cells on tumor growth and progression. The most widely used CAR-T in vivo model is the mouse xenograft model. The in vivo models allow us to assess the efficacy and safety of CAR-T therapy in a living organism.
Reference
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-0120ZP2283 | Anti-C3AR1 (3G7) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 3G7 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2313 | Anti-C3AR1 (7/4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 7/4 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2314 | Anti-C3AR1 (7/4) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 7/4 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2315 | Anti-C3AR1 (XHM27) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | XHM27 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2316 | Anti-C3AR1 (XHM27) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | XHM27 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2317 | Anti-C3AR1 (534625) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 534625 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2318 | Anti-C3AR1 (534625) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 534625 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2319 | Anti-C3AR1 (14D4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 14D4 | Rat | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2320 | Anti-C3AR1 (14D4) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 14D4 | Rat | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP2321 | Anti-C3AR1 (13A35) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 13A35 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| XS-0622-ZP3288 | Anti-C3AR1 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3460 | Anti-C3AR1 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF35 | Anti-Human C3AR1 (XW-35) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-35 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF36 | Anti-Human C3AR1 (XW-36) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-36 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF37 | Anti-Human C3AR1 (XW-37) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-37 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF38 | Anti-Mouse C3AR1 (XW-38) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-38 | Rat | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0123-ZP405 | Anti-C3AR1 (2A1) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | 2A1 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0123-ZP406 | Anti-C3AR1 (3G7) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | 3G7 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0123-ZP407 | Anti-C3AR1 (25H10) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | 25H10 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0123-ZP611 | Anti-C3AR1 (CB-P101) h(scFv-CD3ε) TRuC, pCDTRC1 | Mouse | CB-P101 | Rat | scFv-CD3ε | Lentiviral vector | T cell |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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