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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell. Using its intracellular domain, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 continues to be expressed in most neoplasms derived from T helper cells. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-1022-LX1701 | Anti-CD4 (X10X225) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X225 | Humanized | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1022-LX1702 | Anti-CD4 (X10X226) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X226 | Humanized | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1022-LX1703 | Anti-CD4 (X10X227) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X227 | Rat | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1022-LX1704 | Anti-CD4 (X10X228) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X228 | Mouse | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1022-LX1705 | Anti-CD4 (X10X229) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X229 | Humanized | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1022-LX1706 | Anti-CD4 (X10X230) h(CD28-41BB-CD3ζ) CAR, piggyBac vector system | Human | X10X230 | Humanized | scFv-CD28-41BB-CD3ζ | piggyBac transposon | T cell | ||
| XS-1122-YF6607 | Anti-CD4 (XW-167) h(41BB-CD3ζ) CAR, pAAV | Human | XW-167 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7544 | Anti-CD4 (XW-184) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-184 | Mouse | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-LX274 | Anti-CD4 (X11X274) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X11X274 | Humanized | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX275 | Anti-CD4 (X11X275) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X11X275 | Humanized | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX670 | Anti-CD4 (X11X272) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X11X272 | Humanized | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX671 | Anti-CD4 (X11X273) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X11X273 | Humanized | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX672 | Anti-CD4 (X11X274) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X11X274 | Humanized | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX676 | Anti-CD4 (X11X278) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X11X278 | Humanized | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1064 | Anti-CD4 (X11X268) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X268 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1070 | Anti-CD4 (X11X274) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X274 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1071 | Anti-CD4 (X11X275) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X275 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1072 | Anti-CD4 (X11X276) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X276 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1073 | Anti-CD4 (X11X277) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X277 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-LX1074 | Anti-CD4 (X11X278) h(ICOS-4-1BB-CD3ζ) CAR, pCDCAR1 | Human | X11X278 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0823-LX19 | Anti-hCD4 (17b) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 17b | Adenoviral vectors |
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