CD80

Product List

Please refer to the list below to find the appropriate product for your needs. Creative Biolabs offers a wide range of CD80 CAR related products, including CAR vector products, CAR viral particles, CAR cells, and more.

Background

Cluster of differentiation (CD) 80 is primarily found in immune cells but can also be detected in various cancer cells. This molecule has the ability to either activate or suppress immune reactions. The costimulatory molecule CD80, which can be expressed by antigen-presenting cells (APCs) or tumor cells, interacts with both CD28 and CTLA-4 receptors, regulating the immune response. The interaction between CD28 and CTLA-4 with CD80 is competitive and influenced by factors such as affinity and expression kinetics in T cells. CTLA-4 has a tenfold higher affinity for CD80 compared to CD28. Given the diverse partners of CD80 and their impact on anti-tumor immune responses, it is valuable to study the role of CD80 in the tumor microenvironment and its effect on the effectiveness of cancer therapy.

Associated Diseases

• Breast cancer
• Melanoma
• B-cell lymphoma
• Colorectal cancer

Fig.1 Reverse costimulation through CD80 in modulating the activity of tumor cells.¹

Anti-CD80 CAR-T Services

Anti-CD80 CAR-T In Vitro Assay Services

CD80 CAR-T Expression Test

At Creative Biolabs, a wide range of CD80 protein and cell products can be used to assess the expression levels of CD80 CAR-T cells, gaining valuable insights into the expression patterns and functional capabilities of CD80 CAR-T cells.

• CD80 without any conjugation
• CD80 that is biotinylated
• CD80 labeled with fluorescent tags for easy detection
• Customized cells engineered to overexpress CD80 gene

CD80 CAR-T Cytokine Release Test

We offer CD80 CAR-T cytokine release test services with extensive expertise and advanced technology in immunotherapy research and development. It involves measuring the release of cytokines, such as IL-2, TNF-a, and IFN-g, from CD80 CAR-T cells upon stimulation. This test allows us to assess the potential side effects and immune response triggered by CD80 CAR-T cells.

CD80 CAR-T In Vitro Cytotoxicity Assay

Our CAR-T in vitro cytotoxicity assay is a robust and reliable method for assessing the potency and cytotoxicity of CD80 CAR-T cells. This assay involves co-culturing CD80 CAR-T cells with target cells that express the corresponding antigen. The target cells are labeled with a fluorescent dye, allowing quantification of cell viability and determination of the extent of target cell killing by the CD80 CAR-T cells.

CD80 CAR-T Cell Proliferation Test

Our CD80 CAR-T cell proliferation test provides researchers with essential data and insights into the effectiveness and functionality of CD80 CAR-T cells. By using our test, researchers can determine the proliferation rate of CD80 CAR-T cells in response to specific stimuli, such as the presence of cancer cells or target antigens. This information is crucial as it allows researchers to optimize the design and function of CD80 CAR-T cells for improved therapeutic outcomes.

Anti-CD80 CAR-T In Vivo Assay Services

CD80 CAR-T Cell Therapy Animal Models

We have developed CD80 CAR-T cell therapy animal models to aid researchers in the preclinical evaluation of their therapeutic candidates. These models are instrumental in elucidating the safety, efficacy, and mechanism of action of CD80 CAR-T cell therapies before they advance to clinical trials. In terms of monitoring and assessment, our CD80 CAR-T Cell Therapy Animal Models offer a range of non-invasive imaging modalities to visualize the distribution and persistence of CAR-T cells within the tumor microenvironment. This in-depth analysis offers significant insights into the behavior and effectiveness of CD80 CAR-T cell therapies.

Efficacy Test of CD80 CAR-T

The animal models are injected with tumor cells expressing CD80, and then we evaluate the therapeutic effects of the CD80 CAR-T cells, including measuring tumor size, monitoring tumor growth, and assessing overall survival rates.

Toxicity Evaluation of CD80 CAR-T

We examine various aspects of toxicity in animal models, including acute toxicity, which refers to immediate adverse reactions shortly after treatment, and chronic toxicity, which reflects long-term effects. Our toxicity evaluation will provide recommendations for dose adjustment or intervention measures to minimize toxicity risks.

Reference

1. Mir, M. A. "Concept of reverse costimulation and its role in diseases." Developing costimulatory molecules for immunotherapy of diseases. New York: Elsevier (2015): 45-81.