CD83

Product List

Creative Biolabs is pleased to offer a range of CD83 CAR related products, such as CAR vector products, CAR viral particles, and CAR cells, tailored to meet your specific needs. Our products undergo stringent quality control procedures and leverage scientific expertise, guaranteeing dependable and consistent outcomes.

Background

CD83 molecule plays a crucial role in coordinating appropriate immune responses and promoting the resolution of inflammation.

Associated Diseases

• Acute myeloid leukemia (AML)
• Rheumatoid arthritis rheumatoid arthritis (RA)
• Inflammatory bowel diseases (IBD)
• Diabetes mellitus
• Rift Valley fever
• Graft versus host disease (GVHD)

Fig.1 Human CD83-targeted chimeric antigen receptor T cells can be potentially used to prevent and treat GVHD.¹

Anti-CD83 CAR-T Services

Anti-CD83 CAR-T In Vitro Assay Services

CD83 CAR-T Expression Test

We offer a full range of CD83 proteins and custom cell products to detect the expression of CD83 CAR.

• Unconjugated CD83
• Biotinylated CD83
• Fluorescent-labeled CD83
• Custom cells with CD83 overexpression

CD83 CAR-T Cytokine Release Test

Creative Biolabs has a team of highly skilled scientists and technicians who are experienced in performing the CD83 CAR-T cytokine release test, which is important in understanding the potential side effects and immune response of the therapy. The test helps to identify any excessive or abnormal cytokine release, which can indicate a possible cytokine release syndrome (CRS) or neurotoxicity.

Fig.2 Analysis of IFNγ and IL-2 released by CD83 CAR T cells after stimulation.¹

CD83 CAR-T In Vitro Cytotoxicity Assay

At our state-of-the-art laboratory, we utilize cutting-edge techniques to evaluate the cytotoxic potential of CD83 CAR-T cells in an in vitro setting. The CD83 protein, expressed on dendritic cells, plays a critical role in immune regulation and activation. Our assay allows for the accurate assessment of the potency and efficacy of CD83 CAR-T cells in killing target cells.

Fig.3 Measurement of the cytotoxicity of CD83 CAR T cells.¹

CD83 CAR-T Cell Proliferation Test

The CD83 CAR-T cell proliferation test is a vital component for the evaluation of CAR-T cell therapies. This test allows for an in-depth assessment of the proliferative capacity of CD83-driven CAR-T cells, ensuring their optimal functionality and effectiveness.

Fig.4 Proliferation analysis of CD83 CAR T cells.¹

Anti-CD83 CAR-T In Vivo Assay Services

CD83 CAR-T Cell Therapy Animal Models

Our team of experienced scientists and researchers have developed robust and reliable animal models for CD83 CAR-T cell therapy studies. Our animal models are meticulously designed to accurately mimic the human immune system response to CD83 CAR-T cell therapy. We have accumulated extensive experience in engineering animal models with the stable and durable expression of the CD83 CAR construct.

Fig. 5 Human CD83 CAR T cells prevent xenogeneic GVHD.¹

Efficacy Test of CD83 CAR-T

At our state-of-the-art testing facility, we have a team of highly skilled scientists and technicians who specialize in conducting comprehensive efficacy tests for CD83 CAR-T cells. Our rigorous testing protocols are designed to evaluate the potency and effectiveness of CD83 CAR-T cells in battling cancer cells.

Fig. 6 Human CD83-targeted CAR T cells significantly reduce CD83+ DCs.¹

Toxicity Evaluation of CD83 CAR-T

Our specialized team of experts is skilled in evaluating the toxicity of CD83 CAR-T cells. We perform a series of comprehensive assays to determine any off-target effects.

Creative Biolabs is dedicated to delivering accurate and reliable results, ensuring that our clients receive the highest standard of service.

Reference

1. Shrestha, Bishwas.; et al. "Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease." The Journal of Clinical Investigation 130.9 (2020): 4652-4662.