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Claudins are transmembrane proteins and important components of tight junctions (TJs), which are central for the regulation of paracellular permeability and the maintenance of epithelial cell polarity. The downregulation of several claudins in cancer is consistent with the disruption of TJs during tumorigenesis. However, claudin overexpression, has been reported in various cancers. The dysregulated expression of claudins in cancer occurs at both transcriptional and post-transcriptional level. CLDN6 is expressed in tissues of various cancers while expression in normal non-cancer tissues is limited to placenta. Such cancers include ovarian cancer, in particular ovarian adenocarcinoma and ovarian teratocarcinoma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-0720ZP159 | Anti-CLDN6 (AE3-20) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | AE3-20 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP160 | Anti-CLDN6 (AE3-20) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | AE3-20 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP161 | Anti-CLDN6 (AE49-11) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | AE49-11 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP162 | Anti-CLDN6 (AE49-11) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | AE49-11 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP163 | Anti-CLDN6 (AE1-16) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | AE1-16 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP164 | Anti-CLDN6 (AE1-16) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | AE1-16 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP165 | Anti-CLDN6 (AB3-1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | AB3-1 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP166 | Anti-CLDN6 (AB3-1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | AB3-1 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP167 | Anti-CLDN6 (IMAB 027) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | IMAB 027 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP168 | Anti-CLDN6 (IMAB 027) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | IMAB 027 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP169 | Anti-CLDN6 (61D) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 61D | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP170 | Anti-CLDN6 (61D) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 61D | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP171 | Anti-CLDN6 (89A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 89A | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP172 | Anti-CLDN6 (89A) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 89A | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP173 | Anti-CLDN6 (64-A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 64-A | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP174 | Anti-CLDN6 (64-A) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 64-A | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP175 | Anti-CLDN6 (WU9E1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | WU9E1 | Rat | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP176 | Anti-CLDN6 (WU9E1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | WU9E1 | Rat | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP177 | Anti-CLDN6 (342927) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 342927 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0720ZP178 | Anti-CLDN6 (342927) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 342927 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell |
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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