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General Control Protein GCN4, is a transcription factor for over 30 genes necessary for amino acid or purine biosynthesis in the case of amino acid or purine starvation. As a transcription factor located in the nucleus, GCN4 regulates many genes connected to purine biosynthesis, autophagy, multiple stress responses, glycogen homeostasis, and organelle biosynthesis. A specific antibody conjugated to GCN4 peptide can be used to redirect the activity of the CAR-T cells to antigen expressing cancer cells.
CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
CAR-LC281 | Anti-GCN4 (X8LX1) h(41BB-CD3ζ, GCN4 (X8LX1)) Conditional CAR, pCDCAR1 | Human | X8LX1 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
XS-0922-LX10 | Anti-GCN4 (X9X10) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX11 | Anti-GCN4 (X9X11) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX209 | Anti-GCN4 (X9X10) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX210 | Anti-GCN4 (X9X11) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX408 | Anti-GCN4 (X9X10) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX409 | Anti-GCN4 (X9X11) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
XS-0922-LX607 | Anti-GCN4 (X9X10) Negative Control CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28/CD8TM | Lentiviral vector | T cell | ||
XS-0922-LX608 | Anti-GCN4 (X9X11) Negative Control CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28/CD8TM | Lentiviral vector | T cell | ||
XS-0823-LX50 | Anti-hGCN4 (mabb) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | mabb | Adenoviral vectors |
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