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Her3

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-0323-LX129 Anti-HER3 VHH(X3XH129) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH129 VHH-CD28-41BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX130 Anti-HER3 VHH(X3XH130) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH130 VHH-CD28-41BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX131 Anti-HER3 VHH(X3XH131) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH131 VHH-CD28-41BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX498 Anti-HER3 VHH(X3XH129) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH129 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX499 Anti-HER3 VHH(X3XH130) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH130 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX500 Anti-HER3 VHH(X3XH131) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH131 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX867 Anti-HER3 VHH(X3XH129) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH129 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX868 Anti-HER3 VHH(X3XH130) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH130 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX869 Anti-HER3 VHH(X3XH131) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH131 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0823-LX67 Anti-hHER3 (95) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector Human 95 Adenoviral vectors   Add to Cart   Datasheet
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