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Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also called CD213A2, CT19, IL-13R, IL13BP, is a membrane bound protein that in humans is encoded by the IL13RA2 gene. This protein is a component of the cell surface receptor. Compared to IL-13Rα1, IL-13Rα2 play an opposite role as a potent IL13 antagonist. IL-13Rα2 is infected in the disease of glioblastoma multiforme and malignant glioma though the pathway of immune system and Akt signaling.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-2-M401-BZ | IL13Rα2 h(41BB-CD3ζ) CAR, [T] | Human | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |||
| CAR-T-2-M401-CZ | IL13Rα2 h(b2c-CD3ζ) CAR, [T] | Human | Human | scFv-b2c-CD3ζ | Lentiviral | T cell | |||
| CAR-T-1-M401-2 | IL13Rα2 h(CD28) CAR, [T] | Human | Human | scFv-CD28 | Lentiviral | T cell | |||
| CAR-T-3-M401-2BZ | IL13Rα2 h(CD28-41BB-CD3ζ) CAR, [T] | Human | Human | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |||
| CAR-T-2-M401-2Z | IL13Rα2 h(CD28-CD3ζ) CAR, [T] | Human | Human | scFv-CD28-CD3ζ | Lentiviral | T cell | |||
| CAR-T-2-M401-2G | IL13Rα2 h(CD28-FcεRIγ) CAR, [T] | Human | Human | scFv-CD28-FcεRIγ | Lentiviral | T cell | |||
| CAR-T-3-M401-2XZ | IL13Rα2 h(CD28-OX40-CD3ζ) CAR, [T] | Human | Human | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | |||
| CAR-T-1-M401-Z | IL13Rα2 h(CD3ζ) CAR, [T] | Human | Human | scFv-CD3ζ | Lentiviral | T cell | |||
| CAR-ZP075 | Anti-IL13Rα2 (Hu07H2L) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Hu07H2L | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP076 | Anti-IL13Rα2 (Hu07H2L) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Hu07H2L | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP077 | Anti-IL13Rα2 (Hu08H2L) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Hu08H2L | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP078 | Anti-IL13Rα2 (Hu08H2L) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Hu08H2L | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF391 | Anti-IL13Rα2 (IL13 mutein ((E13K)) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13K) | scFv-41BB-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF392 | Anti-IL13Rα2 (IL13 mutein ((E13Y)) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13Y) | scFv-41BB-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF393 | Anti-IL13Rα2 (IL13 mutein ((E13K.K105R)) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13K.K105R) | scFv-41BB-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF394 | Anti-IL13Rα2 (IL13 mutein ((E13Y.K105R)) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13Y.K105R) | scFv-41BB-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF395 | Anti-IL13Rα2 (IL13 mutein ((E13K)) h(-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13K) | scFv-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF396 | Anti-IL13Rα2 (IL13 mutein ((E13Y)) h(-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13Y) | scFv-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF397 | Anti-IL13Rα2 (IL13 mutein ((E13K.K105R)) h(-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13K.K105R) | scFv-CD3ζ | Lentiviral vector | T Cell | |||
| CAR-YF398 | Anti-IL13Rα2 (IL13 mutein ((E13Y.K105R)) h(-CD3ζ) CAR, pCDCAR1 | Human | IL13 mutein ((E13Y.K105R) | scFv-CD3ζ | Lentiviral vector | T Cell |
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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