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NKG2D

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-SB-LX0376 Anti-NKG2D (KYK-1.0) h(CD28-CD3ζ) CAR, pSBCAR1 Human KYK-1.0 Human scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
CAR-SB-LX0377 Anti-NKG2D (KYK-2.0) h(CD28-CD3ζ) CAR, pSBCAR1 Human KYK-2.0 Human scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-1122-YF588 Anti-NKG2D KIR CAR (scFv-KIR2DS2-DAP12, XW-588), pCDCAR1 Human XW-588 Human scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF589 Anti-NKG2D KIR CAR (scFv-KIR2DS2-DAP12, XW-589), pCDCAR1 Mouse XW-589 Rat scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF590 Anti-NKG2D KIR CAR (scFv-KIR2DS2-DAP12, XW-590), pCDCAR1 Mouse XW-590 Hamster scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF591 Anti-NKG2D KIR CAR (scFv-KIR2DS2-DAP12, XW-591), pCDCAR1 Mouse XW-591 Hamster scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF592 Anti-NKG2D KIR CAR (scFv-KIR2DS2-DAP12, XW-592), pCDCAR1 Mouse XW-592 Rat scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3347 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-587) CAR Plasmid, pCDCAR1 Human XW-587 Human scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3348 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-588) CAR Plasmid, pCDCAR1 Human XW-588 Human scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3349 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-589) CAR Plasmid, pCDCAR1 Mouse XW-589 Rat scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3350 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-590) CAR Plasmid, pCDCAR1 Mouse XW-590 Hamster scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3351 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-591) CAR Plasmid, pCDCAR1 Mouse XW-591 Hamster scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3352 Anti-NKG2D TCR-ABR (scFv-CD3γ, XW-592) CAR Plasmid, pCDCAR1 Mouse XW-592 Rat scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4267 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-587) CAR Plasmid, pCDCAR1 Human XW-587 Human scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4268 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-588) CAR Plasmid, pCDCAR1 Human XW-588 Human scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4269 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-589) CAR Plasmid, pCDCAR1 Mouse XW-589 Rat scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4270 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-590) CAR Plasmid, pCDCAR1 Mouse XW-590 Hamster scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4271 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-591) CAR Plasmid, pCDCAR1 Mouse XW-591 Hamster scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
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