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SIGLEC8

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Sialic acidbinding immunoglobulin (Ig)like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33like subgroup of SIGLECs, which are localized to 19q13.3q13.4 and have 2 conserved cytoplasmic tyrosinebased motifs: an immunoreceptor tyrosinebased inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAMassociated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-0120ZP1119 Anti-SIGLEC8 (EML1447) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse EML1447 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1120 Anti-SIGLEC8 (EML1447) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse EML1447 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1121 Anti-SIGLEC8 (2C4) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 2C4 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1122 Anti-SIGLEC8 (2C4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 2C4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1123 Anti-SIGLEC8 (HEKA) h(CD28-CD3ζ) CAR, pCDCAR1 Humanized HEKA Humanized scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1124 Anti-SIGLEC8 (HEKA) h(4-1BB-CD3ζ) CAR, pCDCAR1 Humanized HEKA Humanized scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1125 Anti-SIGLEC8 (hu2E2) h(CD28-CD3ζ) CAR, pCDCAR1 Humanized hu2E2 Humanized scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1126 Anti-SIGLEC8 (hu2E2) h(4-1BB-CD3ζ) CAR, pCDCAR1 Humanized hu2E2 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1127 Anti-SIGLEC8 (3H1) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 3H1 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1128 Anti-SIGLEC8 (3H1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 3H1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1129 Anti-SIGLEC8 (7C9) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 7C9 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1130 Anti-SIGLEC8 (7C9) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 7C9 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1131 Anti-SIGLEC8 (CBXS-3127) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXS-3127 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1132 Anti-SIGLEC8 (CBXS-3127) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXS-3127 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1133 Anti-SIGLEC8 (CBXS-0373) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXS-0373 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1134 Anti-SIGLEC8 (CBXS-0373) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXS-0373 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1135 Anti-SIGLEC8 (CBXS-3572) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-3572 Human scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1136 Anti-SIGLEC8 (CBXS-3572) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBXS-3572 Human scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1137 Anti-SIGLEC8 (CBXS-5875) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXS-5875 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1138 Anti-SIGLEC8 (CBXS-5875) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXS-5875 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
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