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SLC4A1

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The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The Nterminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated Cterminal membraneassociated domain contains 1214 membrane spanning segments and carries out the stilbene disulphonatesensitive exchange transport of anions. The cytoplasmic tail at the extreme Cterminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-0120ZP1935 Anti-SLC4A1 (5H12) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 5H12 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1936 Anti-SLC4A1 (5H12) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 5H12 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1937 Anti-SLC4A1 (4A3) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 4A3 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1938 Anti-SLC4A1 (4A3) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 4A3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1939 Anti-SLC4A1 (1C4) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 1C4 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1940 Anti-SLC4A1 (1C4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 1C4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1941 Anti-SLC4A1 (CJJJ 247) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CJJJ 247 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1942 Anti-SLC4A1 (CJJJ 247) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CJJJ 247 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1943 Anti-SLC4A1 (BIII.136) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse BIII.136 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1944 Anti-SLC4A1 (BIII.136) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse BIII.136 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1945 Anti-SLC4A1 (DS3305AB) h(CD28-CD3ζ) CAR, pCDCAR1 Rabbit DS3305AB Rabbit scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1946 Anti-SLC4A1 (DS3305AB) h(4-1BB-CD3ζ) CAR, pCDCAR1 Rabbit DS3305AB Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1947 Anti-SLC4A1 (D3X1R) h(CD28-CD3ζ) CAR, pCDCAR1 Rabbit D3X1R Rabbit scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1948 Anti-SLC4A1 (D3X1R) h(4-1BB-CD3ζ) CAR, pCDCAR1 Rabbit D3X1R Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1949 Anti-SLC4A1 (2D5) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 2D5 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-0622-ZP3454 Anti-SLC4A1 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 VHH1-VHH2-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-0123-ZP398 Anti-SLC4A1 (CB-P93) h(scFv-CD3ε) TRuC, pCDTRC1 Human CB-P93 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP603 Anti-SLC4A1 (CB-P94) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse CB-P94 Rat scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0323-ZP398 Anti-SLC4A1 (CB-P93 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human CB-P93 Mouse scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP603 Anti-SLC4A1 (CB-P94 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse CB-P94 Rat scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
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