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Tumor-associated glycoprotein 72 (TAG-72), also known as CA72-4, is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers. It is a mucin-like molecule with a molar mass of over 1000 kDa. TAG-72 is a tumor marker and can be measured with radioimmunoassays like CA 72-4, which uses the monoclonal antibodies indium (111In) satumomab pendetide and iodine (125I) minretumomab. This assay has a good specificity for gastric cancer, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment. TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-M551-G | Anti-TAG-72 VHH h(FcεRIγ) CAR, [T] | Human | CC49 | Humanized | VHH-FcεRIγ | Lentiviral | T cell | ||
| CAR-ZP142 | Anti-TAG-72 (huCC49) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | huCC49 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP143 | Anti-TAG-72 (huCC49) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | huCC49 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP5895 | Anti-TAG-72 (Anatumomab) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Anatumomab | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP5896 | Anti-TAG-72 (Anatumomab) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Anatumomab | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP5897 | Anti-TAG-72 (SPM148) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | SPM148 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP5898 | Anti-TAG-72 (SPM148) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | SPM148 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP5908 | Anti-TAG-72 (Satumomab) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Satumomab | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0822-YF833 | Anti-Human TAG-72 (XW-833) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-833 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1753 | Anti-Human TAG-72 (XW-833) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-833 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2673 | Anti-Human TAG-72 (XW-833) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-833 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-1122-YF833 | Anti-TAG-72 KIR CAR (scFv-KIR2DS2-DAP12, XW-833), pCDCAR1 | Human | XW-833 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1753 | Anti-TAG-72 TCR-ABR (scFv-TCRα, XW-833) CAR Plasmid, pCDCAR1 | Human | XW-833 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2673 | Anti-TAG-72 TCR-ABR (scFv-TCRβ, XW-833) CAR Plasmid, pCDCAR1 | Human | XW-833 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3593 | Anti-TAG-72 TCR-ABR (scFv-CD3γ, XW-833) CAR Plasmid, pCDCAR1 | Human | XW-833 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4513 | Anti-TAG-72 TCR-ABR (scFv-CD3δ, XW-833) CAR Plasmid, pCDCAR1 | Human | XW-833 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5433 | Anti-TAG-72 TCR-ABR (scFv-CD3ε, XW-833) CAR Plasmid, pCDCAR1 | Human | XW-833 | Mouse | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF6353 | Anti-TAG-72 (XW-833) h(CD28-CD3ζ) CAR, pAAV | Human | XW-833 | Mouse | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7273 | Anti-TAG-72 (XW-833) h(41BB-CD3ζ) CAR, pAAV | Human | XW-833 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8193 | Anti-TAG-72 (XW-833) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-833 | Mouse | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell |
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