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TS-Fluc Anti-PSCA (XW-759) BBζ CAR (XS-0822-YF8735)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • PSCA
  • Targeting Diseases
  • Lung Cancer; Pancreatic Cancer; Prostate Cancer; Gastrointestinal Cancers
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ

Target

  • Clone
  • XW-759
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • prostate stem cell antigen
  • Synonyms
  • PSCA;PSCA; prostate stem cell antigen; PRO232;
  • Introduction
  • This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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