Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsClaudins are 20-27kDa transmembrane proteins of tight junctions (TJ) spanning the bilayer four times, where the N-termini and C-termini are oriented towards the cytoplasm and there are two extracellular loop (ECL) domains. Claudins, together with occludins, are the first detected TJ integral proteins and TJ are the most apical type of cell-cell contact existing in the lateral membrane between polarised cells. Therefore, claudins can determine the barrier properties of cell-cell contact among the plasma membranes of two adjacent cells, such as those occurring in endothelia or epithelia. They are expressed in a tissue-specific combination, which leads to tissue-specific barrier characteristics. Claudins can tighten the paracellular cleft for solutes completely and form paracellular ion pores. Mammals express approximately 24 distinct claudins and sequence analysis has fallen them into two groups, designated as classic claudins (1-10, 14, 15, 17, 19) and non-classic claudins (11-13, 16, 18, 20-24), according to their sequence similarity.
Mammalian intracellular claudins exhibit around 7 N-terminal amino acids, 12 loop amino acids, and 25 to 55 C-terminal amino acids, excluding claudin-12, claudin-16, and claudin-23. The ECL 1 is composed of about 50 amino acids with two conserved cysteines implicated in the barrier function. Negative and positive charges in ECL1 contribute to pore formation. The ECL2 generally has approximately 25 amino acids, but fewer in claudin-11 and more in claudin-18. The ECL2 has been less investigated and it probably associates with itself and possesses a holding function. Here show several proteins of the claudin family in humans as bellow.
Based on advanced Magic™ membrane protein production platform, Creative Biolabs would like to offer the preparation of target proteins in requirements by using different strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Here, our Magic™ membrane protein antibody discovery platform can aid to find antibodies against these targets, even fully humanized antibodies, via various techniques including phage display technology, hybridoma technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
