Mouse Anti-Human CD46 Monoclonal Antibody (CTJS-219) [iFluor® 546](Cat#: CTA-672)
This product is a conjugated anti-Human Membrane Cofactor Protein (CD46) Monoclonal antibody (CTJS-219) generated from the Mouse. The antibody can be used for WB, IF, IHC, FC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-219 |
| Host Animal |
Mouse |
| Isotype |
IgG1 κ |
| Immunogen |
Recombinant Human CD46, a.a. 35-328 |
| Species Reactivity |
Human |
| Applications |
WB; IF; IHC; FC |
| Application Notes |
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Membrane Cofactor Protein (CD46). |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
iFluor® 546 |
| Format |
Liquid |
| Size |
200 µg |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
CD46 |
| Alternative Names |
CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; Membrane Cofactor Protein; MCP; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; CD46 |
| Gene ID |
4179 |
| UniProt ID |
P15529 |
Information
| Introduction |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
Acts as a receptor for Adenovirus subgroup B2 and Ad3.
Acts as a receptor for cultured Measles virus.
Acts as a receptor for Herpesvirus 6/HHV-6.
May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
