GTOnco™ Phagocytosis Assay
Phagocytosis is a complex process for the ingestion and elimination of pathogens, and also participates in the elimination of apoptotic cells. The specialized immune cells including macrophages, neutrophils, and dendritic cells have phagocytic functions and also participate in specific immunity, playing an important role in cellular immunity. Creative Biolabs manifests as a world-leading expert in I-O drug discovery field and provides our clients with top-quality phagocytosis assays. Our phagocytosis assay services can be designed to analyze the function of specialized immune cells and evaluate the anti-tumor activity of gene therapy-based I-O products.
Figure 1. The interaction between macrophage and tumor cells. (Lim, 2017)
Phagocytosis comprises a series of events, including the recognition of the target particle, the signaling to activate the internalization machinery, the formation of the phagosome, and the maturation of phagolysosome. Phagocytosis is crucial in fighting infections and is a principal mechanism used to eliminate pathogens and clear cell debris.
At GTOnco™, the phagocytic efficiency can be assayed in vitro by measuring the engulfment of a cell substrate. The most common substrates such as red blood cells (RBCs), E. coli, and zymosan (yeast) particles are available for your selection. Our platforms have developed various types of in vitro phagocytosis assays to evaluate the effect of gene therapy-based I-O agents, including flow assay based on flow cytometry and classical phagocytosis assay. We are committed to providing the custom phagocytosis assays to promote our clients' projects to clinical stage.
Features of Our Phagocytosis Assays at GTOnco™ Platform
- Custom assay services and advanced analysis techniques are available;
- Various types of specialized immune cells we can handle: macrophages, neutrophils, and dendritic cells;
- Fast turnaround time and superior quality.
Taking advantage of the GTOnco™ platform, Creative Biolabs is able to conduct many in vitro tests to evaluate the phagocytic functions and therapeutic efficacy of gene therapy-based I-O drugs. we will apply the rigorous criteria to generate reliable and solid data for every research project. For more detailed information, please feel free to contact us.
References
- Rosales, C. and Uribe-Querol, E. (2017). Phagocytosis: A Fundamental Process in Immunity. BioMed Research International. pp.1-18.
- Lim, J.; et al. (2017). Diversity and Versatility of Phagocytosis: Roles in Innate Immunity, Tissue Remodeling, and Homeostasis. Frontiers in Cellular and Infection Microbiology. 7.
