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Magic™ Recombinant Human CXCR3 Membrane Protein in Virus-Like Particles (MP-VLPs) (CAT#: MPVLP-013)

Datasheet
This product is recombinant Human CXCR3 in VLPs form. This product is produced from mammalian cells by co-expressing the retroviral structural core polyprotein (gag) and the target membrane protein. MP-VLPs display highly-expressed copies of membrane proteins in their native conformation, providing an alternative to membrane protein stable cell lines, membrane preparations, detergent-solubilized proteins and other membrane protein preparation strategies. MP-VLPs can be used for a wide range of applications in antibody production, antibody discovery, antibody characterization, binding assays and functional assays.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CXCR3
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • TMD
  • 7

Product Description

  • Application
  • ELISA; Antibody Production; Antibody Discovery; Antibody Characterization; Binding Assays; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Protein Format
  • Membrane Protein-Virus Like Particles (MP-VLPs)

Target

  • Target Protein
  • CXCR3
  • Full Name
  • C-X-C motif chemokine receptor 3
  • Introduction
  • This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
  • Alternative Names
  • GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; G protein-coupled receptor 9; IP-10 receptor; Mig receptor; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; interferon-inducible protein 10 receptor

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