Creative Biolabs is committed to the development of tumor immunotherapy technology and cell therapy products. Supported by in-house scientists and a first-in-class technological platform, we are dedicated to developing engineered colorectal cancer cells CACO2 for self-destruction.

CACO2 Cell Line

Caco2 is a cell line derived from a primary colonic tumor obtained from a 72-year-old patient and is widely known for its rapid differentiating ability. It has been widely used as a model of the intestinal epithelial barrier. This cell line is heterogeneous and contains cells with slightly different properties. Caco2 cells differ from normal enterocytes for mutations of APC and β-catenin genes. It can be used as a model to study the immune response of intestinal epithelial cells and their involvement in pathology. Caco2 is a suitable transfection host and has applications in cancer and toxicology research for certain types of colon cancer in humans.

Engineering CACO2 Service

Our scientists are dedicated to getting access to the most complete solution to develop and assess gene-modified CACO2 cells. Our clients can choose different strategies for engineering cancer cells to achieve their goals. We are committed to guaranteeing our clients can receive fully compliant data in the desired timeline.

• Different Cytokines Overexpression

Engineering CACO2 cells with cytokine overexpression may enhance antitumor immunity since

• ✔ The whole tumor cell provides a polyvalent source of tumor-associated antigens;
• ✔ The secretion of cytokine by the modified tumor cells can greatly enhance the immune response.

Cytokines have a wide range of roles in the immune system's response to disease. We have developed engineered CACO2 cells modified with cytokines to activate the immune system and destruct tumors. The following are a variety of cytokines to engineer for your choice.

• Assessment of Engineered CACO2 cells

Creative Biolabs provides a one-stop platform for the development of engineered cancer cells for self-destruction. Our end-to-end services include but not limited to:

Creative Biolabs is committed to providing custom portfolio services to meet all the needs of our customers. If you are interested in our services, please don't hesitate to contact us to discuss your project.

References

1. Nagai, E.; et al. Irradiated tumor cells adenovirally engineered to secrete granulocyte/macrophage-colony-stimulating factor establish antitumor immunity and eliminate pre-existing tumors in syngeneic mice. Cancer Immunology, Immunotherapy. 1998, 47(2): 72-80.
2. Nemunaitis, J. Vaccines in cancer: GVAX®, a GM-CSF gene vaccine. Expert review of vaccines. 2005, 4(3): 259-274.

For Research Use Only | Not For Clinical Use