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Magic™ Antibody Discovery - Cynomolgus IL-17A / CTLA-8 (24-155) Membrane Protein, Partial, His- tag (CAT#: MP0299F)

Datasheet
This membrane protein is Cynomolgus IL-17A / CTLA-8 (24-155). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus
  • Target Protein
  • IL-17A / CTLA-8
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 17.0 kDa.
  • Sequence
  • AA Gly 24 - Ala 155 (Accession # G7P4U9-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Please contact us for detailed information.

    Contact us for customized product form or formulation.

Target

  • Target Protein
  • IL-17A / CTLA-8
  • Full Name
  • interleukin 17A
  • Introduction
  • This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
  • Alternative Names
  • IL-17A, Interleukin-17A, CTLA-8, IL-17

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