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Magic™ Antibody Discovery - Human ACE2 / ACEH (18-740) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0886F)

Datasheet
This membrane protein is Human ACE2 / ACEH (18-740). It has been tested in SDS-PAGE, SEC-SEC-MALS, ELISA, BLI, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACE2 / ACEH
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 110.0 kDa. The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 18 - Ser 740 (Accession # Q9BYF1-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SEC-SEC-MALS, ELISA, BLI, SPR
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, Arginine, pH7.5 with glycerol as protectant.

Target

  • Target Protein
  • ACE2 / ACEH
  • Full Name
  • angiotensin I converting enzyme 2
  • Introduction
  • The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19).
  • Alternative Names
  • ACE2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme 2, metalloprotease MPROT15, ACE-related carboxypeptidase, angiotensin I converting enzyme 2, angiotensin-converting enzyme homolog, ACEH,

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