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Magic™ Antibody Discovery - Human CADM1 / IGSF4A (45-374) Membrane Protein, Partial, -His tag (CAT#: MP1088F)

Datasheet
This membrane protein is Human CADM1 / IGSF4A (45-374). It has been tested in SDS-PAGE, ELISA, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CADM1 / IGSF4A
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 37.9 kDa. The protein migrates as 50 kDa and 55-85 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
  • Sequence
  • AA Gln 45 - His 374 (Accession # NP_055148.3).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, BLI
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CADM1 / IGSF4A
  • Full Name
  • cell adhesion molecule 1
  • Introduction
  • Mediates homophilic cell-cell adhesion in a Ca2+-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536).
  • Alternative Names
  • CADM1, cell adhesion molecule 1, IGSF4, immunoglobulin superfamily, member 4 , TSLC1, tumor suppressor in lung cancer 1, BL2, IGSF4A, Necl 2, NECL2, nectin like 2, RA175, ST17, SYNCAM, SYNCAM1, TSLC-1, nectin-like 2, nectin-like protein 2, truncated CADM1 protein, TSLC1/Nectin-like 2/IGSF4, synaptic cell adhesion molecule, tumor suppressor in lung cancer 1, immunoglobulin superfamily member 4, immunoglobulin superfamily, member 4, spermatogenic immunoglobulin superfamily, immunoglobulin superfamily, member 4D variant 2, IGSF4, TSLC1, Necl-2, sgIGSF, sTSLC-1, synCAM1, MGC51880, MGC149785, DKFZp686F1789,

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