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Magic™ Antibody Discovery - Human Cathepsin L / CTSL1 (18-333) Membrane Protein, Partial, -His tag (CAT#: MP1084F)

Datasheet
This membrane protein is Human Cathepsin L / CTSL1 (18-333). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Cathepsin L / CTSL1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 25.0 kDa. The protein migrates as 10 kDa and 34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation, corresponding to the propeptide and the mature form respectively.
  • Sequence
  • AA Thr 18 - Val 333 (Accession # NP_001903.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >98% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 20 mM NaAc, 150 mM NaCl, pH5.0. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Cathepsin L / CTSL1
  • Full Name
  • cathepsin L
  • Introduction
  • The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
  • Alternative Names
  • CTSL1, cathepsin L1, cathepsin L , CTSL, FLJ31037, cathepsin L, major excreted protein, MEP, CATL, CTSL,

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