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Magic™ Antibody Discovery - Human CBLB / RNF56 (39-426) Membrane Protein, Partial, His- Avi- tag, [Biotin] (CAT#: MP1181F)

Datasheet
This membrane protein is Human CBLB / RNF56 (39-426). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CBLB / RNF56
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 47.9 kDa. The protein migrates as 45 kDa and 46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ala 39 - Phe 426 (Accession # Q13191-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • E.coli
  • Tag
  • His tag at the N-terminus, followed by an Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 40 mM HEPES, 120 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CBLB / RNF56
  • Full Name
  • Cbl proto-oncogene B
  • Introduction
  • This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections.
  • Alternative Names
  • CBLB, Cbl proto-oncogene, E3 ubiquitin protein ligase B, Cas Br M (murine) ecotropic retroviral transforming sequence b , Cas Br M (murine) ectropic retroviral transforming sequence b, E3 ubiquitin-protein ligase CBL-B, Cbl b, RNF56, RING finger protein 56, SH3-binding protein CBL-B, signal transduction protein CBL-B, casitas B-lineage lymphoma proto-oncogene b, Cas-Br-M (murine) ectropic retroviral transforming sequence b, Cas-Br-M (murine) ecotropic retroviral transforming sequence b, Cbl-b, Nbla00127, FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223,

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