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Magic™ Antibody Discovery - Human IL-2 R beta&IL-2 R gamma (27-239(IL-2RB)&23-254(IL-2RG)) Membrane Protein, Partial, -hIgG1 Fc -Avi tag & -hIgG1 Fc -Avi tag, [Biotin] (CAT#: MPX4720K)

Datasheet
This membrane protein is Human IL-2 R beta&IL-2 R gamma. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-2 R beta&IL-2 R gamma
  • Protein Length
  • ECD
  • Protein Class
  • Receptor
  • Molecular Weight
  • 52.8 kDa (IL-2RB) and 55.3 kDa (IL-2RG)
  • TMD
  • 1
  • Sequence
  • AA Ala 27 - Asp 239 (IL-2RB) & Leu 23 - Asn 254 (IL-2RG) (Accession # P14784-1(IL-2RB) & P31785-1(IL-2RG))

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • Subunit IL-2RB is fused with a human IgG1 Fc tag at the C-terminus, followed by a Avi tag and subunit IL-2RG is fused with a human IgG1 Fc tag at the C-terminus, followed by a Avi tag.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU per μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4

Target

  • Target Protein
  • IL-2 R beta&IL-2 R gamma
  • Full Name
  • Interleukin 2 receptor subunit beta & Interleukin 2 receptor subunit gamma
  • Introduction
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. & The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
  • Alternative Names
  • IL-2 R beta & IL-2 R gamma, IL-2RB & IL-2RG

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