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Magic™ Antibody Discovery - Human IL-23 alpha & Mouse IL-12 beta Heterodimer (20-189(IL23A)&23-328(IL12B)) Membrane Protein, Partial, His- Tag & Tag free (CAT#: MP0317F)

Datasheet
This membrane protein is Human IL-23 alpha & Mouse IL-12 beta Heterodimer (20-189(IL23A)&23-328(IL12B)). It has been tested in SDS-PAGE, ELISA, BLI, Cell based assay, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-23 alpha & Mouse IL-12 beta Heterodimer
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). The reducing (R) protein migrates as 20 kDa (IL-23 alpha) and 37-45 kDa (IL-12 beta) respectively due to glycosylation.
  • Sequence
  • AA Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P29460-1 (IL12B)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, BLI, Cell based assay, SPR
  • Expression Systems
  • HEK293
  • Tag
  • IL-23 alpha is fused with His tag at the N-terminus. and subunit IL-12 beta contains no tag.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-23 alpha & Mouse IL-12 beta Heterodimer
  • Full Name
  • interleukin 23 subunit alpha&interleukin 12b
  • Introduction
  • This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. &This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23.
  • Alternative Names
  • IL-23 alpha & IL-12 beta

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