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Magic™ Antibody Discovery - Human Integrin alpha 3 beta 1 (33-991(ITGA3)&21-728(ITGB1)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0382F)

Datasheet
This membrane protein is Human Integrin alpha 3 beta 1 (33-991(ITGA3)&21-728(ITGB1)). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha 3 beta 1
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 133.3 kDa (ITGA3) and 83.7 kDa (ITGB1). The non-reducing (NR) protein migrates as 125-150 kDa (ITGA3) and 100-110 kDa (ITGB1) respectively due to glycosylation.
  • Sequence
  • AA Phe 33 - Glu 991 (ITGA3) & Gln 21 - Asp 728 (ITGB1) (Accession # P26006-2 (ITGA3) & P05556-1 (ITGB1)).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • ITGA3 is fused with an acidic tail at the C-terminus. and followed by His tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha 3 beta 1
  • Full Name
  • integrin subunit alpha 3&integrin subunit beta 1
  • Introduction
  • The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. &Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Alternative Names
  • Integrin alpha 3 beta 1, ITGA3&ITGB1

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