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Magic™ Antibody Discovery - Human Leptin R / CD295 (22-839) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0568F)

Datasheet
This membrane protein is Human Leptin R / CD295 (22-839). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Leptin R / CD295
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 119.6 kDa. The protein migrates as 150-165 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Phe 22 - Asp 839 (Accession # NP_002294.2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Leptin R / CD295
  • Full Name
  • leptin receptor
  • Introduction
  • The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins
  • Alternative Names
  • OBR; OB-R; CD295; LEP-R; LEPRD; leptin receptor; OB receptor; huB219

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