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Magic™ Antibody Discovery - Human R-Spondin 1 / RSPO1 (21-263) Membrane Protein, Partial, -His tag (CAT#: MP0829F)

Datasheet
This membrane protein is Human R-Spondin 1 / RSPO1 (21-146). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • R-Spondin 1 / RSPO1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 28.7 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ser 21 - Ala 263 (Accession # Q2MKA7-1)

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His Tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • R-Spondin 1 / RSPO1
  • Full Name
  • R-spondin 1
  • Introduction
  • This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • RSPO; CRISTIN3; R-spondin-1; R-spondin homolog; roof plate-specific spondin-1

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