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Magic™ Antibody Discovery - Human TrkB / NTRK2 (32-430) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0466F)

Datasheet
This membrane protein is Human TrkB / NTRK2 (32-430). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TrkB / NTRK2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 70.4 kDa. The protein migrates as 86-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Cys 32 - His 430 (Accession # AAH31835).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >98% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TrkB / NTRK2
  • Full Name
  • neurotrophic receptor tyrosine kinase 2
  • Introduction
  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine kinase receptor type 2; tropomyosin-related kinase B; tyrosine kinase receptor B

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