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Magic™ Antibody Discovery - Mouse ACE2 / ACEH (18-740) Membrane Protein, Partial, His- tag (CAT#: MP0889F)

Datasheet
This membrane protein is Mouse ACE2 / ACEH (18-740). It has been tested in SDS-PAGE, SEC-SEC-MALS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • ACE2 / ACEH
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 85.4 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 18 - Thr 740 (Accession # Q8R0I0-1).

Product Description

  • Application
  • SDS-PAGE, SEC-SEC-MALS
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, Arginine, pH7.5 with glycerol as protectant.

Target

  • Target Protein
  • ACE2 / ACEH
  • Full Name
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
  • Introduction
  • Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity).
  • Alternative Names
  • ACE2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme 2, 2010305L05Rik,

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