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Magic™ Antibody Discovery - Mouse CCL6 / C10 (22-116) Membrane Protein, Partial, -His tag (CAT#: MP1068F)

Datasheet
This membrane protein is Mouse CCL6 / C10 (22-116). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • CCL6 / C10
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 11.7 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Gly 22 - Ala 116 (Accession # P27784).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CCL6 / C10
  • Full Name
  • chemokine (C-C motif) ligand 6
  • Introduction
  • This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.
  • Alternative Names
  • MRP; Scy; c10; MRP-1; Scya6; C-C motif chemokine 6; CC chemokine C10; small-inducible cytokine A6

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