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Magic™ Human AXL BaF3 Cell Line (CAT#: S01YF-1222-KX826)

Datasheet
This product is a BaF3 stable cell line. It stably expresses Human AXL to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • AXL
  • Target Protein Species
  • Human
  • Accession Number
  • NM_001699.3
  • Protein Tag
  • Tag-free
  • Host Cell Type
  • BaF3
  • Target Classification
  • Kinases/Enzyme
  • Target Family
  • Kinases/Enzyme
  • Target Research Area
  • Metabolic Research
  • Related Diseases
  • Hypogonadotropic Hypogonadism; Nk-Cell Enteropathy

Product Properties

  • Morphology
  • Suspension
  • Assay Types
  • Drug screening and biological assays
  • Resistance
  • Puromycin
  • Stability
  • 10 passages
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 5x10⁶ cells
  • Form
  • Frozen cells
  • Freeze Medium
  • 70% RPMI 1640 + 20% FBS + 10% DMSO
  • Culture Medium
  • RPMI 1640 + 10% FBS
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • AXL receptor tyrosine kinase
  • Introduction
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
  • Alternative Names
  • AXL; ARK; UFO; JTK11; Tyro7; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene; AXL receptor tyrosine kinase

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