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Magic™ Human IL2RB HEK293T Cell Line (CAT#: S01YF-0123-KX286)

Datasheet
This product is a HEK293T stable cell line. It stably expresses Human IL2RB to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • IL2RB
  • Target Protein Species
  • Human
  • Accession Number
  • NM_000878.5
  • Protein Tag
  • Tag-free
  • Host Cell Type
  • HEK293T
  • Target Classification
  • Immune Checkpoint
  • Target Family
  • Immune Checkpoint
  • Target Research Area
  • Autoimmune Research; Immunology Research
  • Related Diseases
  • Immunodeficiency; Ichthyosis

Product Properties

  • Morphology
  • Fibroblastoid cells growing as a monolayer
  • Assay Types
  • Drug screening and biological assays
  • Resistance
  • Puromycin
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • 10 passages
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 5x10⁶ cells
  • Form
  • Frozen cells
  • Freeze Medium
  • 70% DMEM + 20% FBS + 10% DMSO
  • Culture Medium
  • DMEM + 10% FBS + 0.5µg/mL Puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Interleukin 2 receptor subunit beta
  • Introduction
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
  • Alternative Names
  • IL2RB; CD122; IMD63; IL15RB; P70-75; interleukin-2 receptor subunit beta; CD122 antigen; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; interleukin 15 receptor, beta; interleukin 2 receptor, beta; interleukin-15 receptor subunit beta; p75; Interleukin 2 receptor subunit beta

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