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Magic™ Human OTOF Membrane Protein Expressed in E. coli, Partial (1461-1868 aa) (CAT#: S01YF-0824-KX1)

This product is recombinant Human OTOF protein.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OTOF
  • Protein Length
  • ECD
  • Protein Class
  • Receptor
  • Molecular Weight
  • 52.6 kDa
  • TMD
  • 1
  • Sequence
  • KVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDK
    ENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQT
    YSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEH
    VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRK
    PKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRY
    LFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTA
    KQCTMEM

Product Description

  • Expression Systems
  • E. coli expression system
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • OTOF
  • Full Name
  • Otoferlin
  • Introduction
  • Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene.
  • Alternative Names
  • OTOF; AUNB1; DFNB6; DFNB9; NSRD9; FER1L2; fer-1-like family member 2; fer-1-like protein 2; Otoferlin
  • Gene ID
  • 9381
  • UniProt ID
  • Q9HC10

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