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Magic™ Membrane Protein Human ADRA2A (Adrenoceptor alpha 2A) Full Length (CAT#: MPC0028K) Made to Order

Datasheet
This product is a 50.6 kDa Human ADRA2A membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADRA2A
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 50.6 kDa
  • TMD
  • 7
  • Sequence
  • MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLT
    LVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATL
    VIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSI
    TQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAE
    PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG
    PDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
    RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRR
    GPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVV
    CWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR
    AFKKILCRGDRKRIV

Product Description

  • Expression Systems
  • Baculovirus/Insect expression system
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ADRA2A
  • Full Name
  • Adrenoceptor alpha 2A
  • Introduction
  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established.
  • Alternative Names
  • ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ADRA2A; Adrenoceptor alpha 2A

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