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Magic™ Membrane Protein Human APLNR (Apelin receptor) (CAT#: MP0001F)

Datasheet
The apelin receptor (AR or APJ) is a class A GPCR involved in numerous physiological processes. The apelin receptor is implicated in angiogenesis during tumour formation and as a CD4 co-receptor for entry of human immunodeficiency virus type 1 (HIV-1) to cells.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • APLNR
  • Protein Length
  • Full Length
  • Protein Class
  • GPCR Class A
  • Molecular Weight
  • 42.66kDa
  • TMD
  • 7
  • Sequence
  • MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
    RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
    TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
    CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
    RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
    NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
    GGEQMHEKSIPYSQETLVVD

Product Description

  • Activity
  • Validated by SPRi
  • Application
  • Screening & Display Technologies, Structural Biology, Antibody development
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end and Streptavidin tag fused to the C-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >70% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • APLNR
  • Full Name
  • Apelin receptor
  • Introduction
  • This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
  • Alternative Names
  • APJ, APJR, HG11, AGTRL1

Customer reviews and Q&As    

Q&As

What is the metabolic mechanism of APLNR?

The relevant literature suggests that furin (also known as PCSK3), plasma kallikrein, and neprilysin cleave apelin peptides, but only neprilysin has been shown to completely inactivate these peptides.
2022-11-01

How to increase the soluble expression ratio and expression amount of APLNR protein?

Usually, the soluble ratio and expression of APLNR protein can be effectively increased by gene optimization, vector and strain screening, expression condition optimization, and induction condition optimization.
2022-11-01

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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