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Magic™ Membrane Protein Human APLP1 (Amyloid beta precursor like protein 1) Expressed in NS0 for Antibody Discovery, Partial (34-580aa) (CAT#: MPX0247K)

Datasheet
This product is a 62 kDa Human APLP1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • APLP1
  • Protein Length
  • Partial (34-580aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 62 kDa
  • TMD
  • 1
  • Sequence
  • QPAIGSLAGGSPGAAEA
    PGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYP
    ELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEAL
    LVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSD
    RFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFP
    QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
    PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQAL
    NEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ
    ADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVH
    THLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAP
    GGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV
    NASVPRGFPFHSSEIQRDELAPAGTGVSRE

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • APLP1
  • Full Name
  • Amyloid beta precursor like protein 1
  • Introduction
  • This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Alternative Names
  • APLP1; APLP; amyloid-like protein 1; amyloid beta (A4) precursor-like protein 1; amyloid precursor-like protein 1; Amyloid beta precursor like protein 1

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