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Magic™ Membrane Protein Human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Full Length (CAT#: MPC1148K) Made to Order

Datasheet
This product is a 114.7 kDa Human ATP2A2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP2A2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 114.7 kDa
  • TMD
  • 10
  • Sequence
  • MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLL
    ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVA
    NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDI
    VEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAV
    NQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ
    QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAV
    ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS
    DKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDK
    PVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
    KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTP
    NKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIRE
    WGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLD
    PPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSK
    AFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMT
    GDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGR
    AIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDG
    LPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGA
    AAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMAL
    SVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVE
    PLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQP
    ATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP2A2
  • Full Name
  • ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  • Introduction
  • This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • ATP2A2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2; calcium pump 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

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